Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation

Objective. To investigate intrathecal immune activation parameters and HIV-RNA in HIV-associated neurocognitive disorders (HAND) of advanced naïve HIV-infected patients and to evaluate their dynamics before and after initiation of antiretroviral therapy (ART). Methods. Cross-sectional and longitudinal analysis of HIV RNA, proinflammatory cytokines (IL-6, IL-10, INF-γ, TNF-α, TGF-β1, and TGF-β2) and chemokines (MIP-1α, MIP-1β, and MCP-1) in plasma and cerebrospinal fluid (CSF) of HIV-infected patients with CD4 <200/μL. Results. HAND was diagnosed at baseline in 6/12 patients. Baseline CSF HIV-RNA was comparable in patients with or without HAND, whereas CSF concentration of IL-6 and MIP-1β, proinflammatory cytokines, was increased in HAND patients. CSF evaluation at 12 weeks was available in 10/12 cases. ART greatly reduced HIV-RNA in all patients. Nevertheless, IL-6 and MIP-1β remained elevated after 12 weeks of therapy in HAND patients, in whom CSF HIV RNA decay was slower than the plasmatic one as well. Conclusion. Immune activation, as indicated by inflammatory cytokines, but not higher levels of HIV-RNA is observed in advanced naïve HIV-infected patients with HAND. In HAND patients, ART introduction resulted in a less rapid clearance of CSF viremia compared to plasma and no modifications of intratechal immune activation

18. Sessió 5. Els projectes que no vam construir / Benedetta Tagliabue

Conferència de Benedetta Tagliabue, Arquitecte i sòcia de la firma EMBT des de 1992, per a la sessió 5. Arquitectura: la institucionalització d'una poètica

Time two

[ES] Recordar a Enric me encanta. Ha sido mi manera de llevar estos últimos veinte años sin él.[EN] love reminiscing about Enric. It has been my way of getting through these last twenty years without him.Tagliabue, B. (2020). Tiempo dos. EN BLANCO. Revista de Arquitectura. 12(29):62-63. https://doi.org/10.4995/eb.2020.14383OJS6263122

Benedetta Taglibue in conversation with Javier Fernández Contreras ::Enric Miralles and the Hockney Collages

In this interview, Benedetta Tagliabue explores the origins of Enric Miralles’ interest in the photographic work of David Hockney, as well as the further exploration of the photo collage as a design mechanism in the work of Miralles/Tagliabue in the 1990s

Integrar les diferències

Peer Reviewe